SnapShot: Nuclear Receptors I
نویسندگان
چکیده
Estrogen receptors* ERα/NR3A1; ERβ/NR3A2 Endogenous: 17β-estradiol Regulation of cell growth and proliferation in multiple tissues (e.g., female reproductive tissues, bone, and CNS) Cancer, cardiovascular, immune and inflammatory, metabolic, neurological, reproductive ↑ MYC, NGF, BCL2, CXCL2, IGF1, TYMS; ↓ CD36, NDRG1, NCOR1, NCOA3 Clinical: Mixed agonists (e.g. tamoxifen, raloxifene, and toremifene in breast cancer)
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عنوان ژورنال:
- Cell
دوره 142 شماره
صفحات -
تاریخ انتشار 2010